A new, one-pot, multi-component synthesis of imines of 3-amino-2-arylimidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines

作者：Abid Mehdi^*; Sheibani Esmail; Bijanzadeh Hamid Reza; Zhu Long Guan

来源：Tetrahedron, 2008, 64(47): 10681-10686.

DOI：10.1016/j.tet.2008.09.002

• 2-Aminopyridines
• 2-Aminopyrazine
• 2-Aminopyrimidine
• Benzaldehydes
• Imidazoline-2,4,5-trione
• 3-Amino-2-arylimidazo[1,2-a]pyridines
• 3-Amino-2-arylimidazo[1,2-a]pyrazines
• 3-Amino-2-arylimidazo[1,2-a]pyrimidines
• Multi-component reactions

An efficient, one-pot, multi-component synthesis of 3-amino-2-arylmidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines is described. Heating a Mixture of a 2-aminopyridine, 2-aminopyrazine or 2-aminopyrimidine, a benzaldehyde, and imidazoline-2,4,5-trione Under solvent-free conditions afforded imine derivatives of the title compounds in excellent yields. Single-crystal X-ray analysis conclusively confirms the structure of these bridgehead bicyclic 5-6 heterocycles.

• 出版日期2008-11-17
• 单位浙江大学