New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product

作者：Divers Thomas J; Tennant Bud C; Kumar Arvind; McDonough Sean; Cullen John; Bhuva Nishit; Jain Komal; Chauhan Lokendra Singh; Scheel Troels Kasper Hoyer; Lipkin W Ian; Laverack Melissa; Trivedi Sheetal; Srinivasa Satyapramod; Beard Laurie; Rice Charles M; Burbelo Peter D; Renshaw Randall W; Dubovi Edward; Kapoor Amit^*

来源：Emerging Infectious Diseases, 2018, 24(2): 303-310.

DOI：10.3201/eid2402.171031

Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.

• 出版日期2018-2