Mastocytosis-induced osteoporosis

作者：Maier G S^*; Percic D; Maus U; Kurth A A

来源：Osteologie, 2013, 22(2): 136-139.

• Mast cells
• mastocytosis
• osteoporosis

Background: Systemic mastocytosis is a rare disease characterised by accumulation of mast cells in at least one extracutaneous organ, including bone marrow. It is increasingly recognized as a possible cause of secondary osteoporosis. We conducted a literature review on the role of mast cells in osteoporosis including data/peer reviewed articles/journals from 1957 to 2012. Our aim was to evaluate the current state of research; and to offer an overview of current therapeutic options/measures/treatments. %26lt;br%26gt;Methods: A retrospective review of peer reviewed/published literature was performed; using MEDLINE databases from 1957 to 2012. The keywords %26quot;osteoporosis%26quot; and %26quot;mast cells/mastocytosis%26quot; revealed 201 articles, limited to English and German articles., The following criteria were included: studies on, or case studies of either mastocytosis induced osteoporosis, or the role of mast cells in osteoporosis or the relation of bone remodeling and mastocytosis. %26lt;br%26gt;Results/Conclusion: Mast cells seem to play an important role in bone turnover. Their byproducts are responsible for increased bone resorption. However, the skeletal involvement is mainly situated in trabecular bone, which determines vertebral collapse. This review increases the awareness that patients with systemic mastocytosis would benefit from diagnostic workup with regard to bone health, as this rather rare cause of secondary osteoporosis can lead to significantly high rates of mortality.

• 出版日期2013