Fetal Growth Restriction with Brain Sparing: Neurocognitive and Behavioral Outcomes at 12 Years of Age

作者：Beukers Fenny; Aarnoudse Moens Cornelieke S H; van Weissenbruch Mirjam M; Ganzevoort Wessel; van Goudoever Johannes B; van Wassenaer Leemhuis Aleid G

来源：Journal of Pediatrics, 2017, 188: 103-+.

DOI：10.1016/j.jpeds.2017.06.003

Objective To study neurocognitive functions and behavior in children with a history of fetal growth restriction (FGR) with brain sparing. We hypothesized that children with FGR would have poorer outcomes on these domains.
Study design Subjects were 12-year-old children with a history of FGR born to mothers with severe early-onset hypertensive pregnancy disorders (n = 96) compared with a normal functioning full term comparison group with a birth weight = 2500 g (n = 32). Outcome measures were neurocognitive outcomes (ie, intelligence quotient, executive function, attention) and behavior.
Results For the FGR group, the mean ratio of the pulsatility index for the umbilical artery/middle cerebral artery (UC-ratio = severity of brain sparing) was 1.42 +/- 0.69. The mean gestational age was 31-6/7 +/- 2-2/7 weeks. The mean birth weight was 1341 +/- 454 g, and the mean birth weight ratio 0.68 +/- 0.12. Neurocognitive outcomes were comparable between groups. Parents of children with FGR reported more social problems (mean T-score 56.6 +/- 7.7; comparison 52.3 +/- 4.3, P < .001, effect size = 1, 95% CI 0.52-1.46) and attention problems (mean T-score 57.3 +/- 6.9; comparison 53.6 +/- 4.2, P = .004, effect size = 0.88, 95% CI 0.42-1.33). UC-ratio was not associated with any of the outcomes, but low parental education and lower birth weight ratio were.
Conclusions In this prospective follow-up study of 12-year-old children with a history of FGR and confirmed brain sparing, neurocognitive functions were comparable with the comparison group, but parent-reported social and attention problem scores were increased.

• 出版日期2017-9