Direct addition of 2-methylazines to aryl glyoxals for the synthesis of alpha-hydroxy ketones

作者：Li Binbin; Wei Huiping; Li Haiyan; Pereshivko Olga P; Peshkov Vsevolod A^*

来源：Tetrahedron Letters, 2015, 56(37): 5231-5234.

DOI：10.1016/j.tetlet.2015.07.053

• 2-Methylazines
• Aryl glyoxals
• alpha-Hydroxyketones
• Azaarenes

A catalyst-free protocol for the reaction of 2-methylazines and aryl glyoxal hydrates leading to alpha-hydroxy ketones bearing azaarene moiety is described. The process is operationally simple and can be applied to a broad range of substrates.

• 出版日期2015-9-9
• 单位苏州大学