Antimicrobial activity of hydroxylbenzenesulfonailides derivatives of chitosan, chitosan sulfates and carboxymethyl chitosan

作者：Zhong Zhimei^*; Li Pengcheng; Xing Ronge; Liu Song

来源：International Journal of Biological Macromolecules, 2009, 45(2): 163-168.

DOI：10.1016/j.ijbiomac.2009.04.020

• Hydroxylbenzenesulfonailides
• Chitosan
• Carboxymethyl chitosan
• Chitosan sulfate
• Antimicrobial activity

Chitosan, carboxymethyl chitosan (CIVICS) and chitosan sulfates (CSS) with different molecular weight were modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3 -benzene-disulfo-chloride to give 12 kinds of new hydroxylbenzenesulfonailides derivatives of them. The preparation conditions of the derivatives were discussed in this paper, and their structures were characterized by FT-IR and (13)C NMR spectroscopy. The solubility of the derivatives was measured in the experiment. In addition, their antimicrobial activities against four bacteria and five crop-threatening pathogenic fungi were tested in the experiment. Besides, the rule and mechanism of their antibacterial activities were discussed in this paper.

• 出版日期2009-8-1
• 单位中国科学院海洋研究所; 内蒙古农业大学