A Model for Predicting the Optimal Conditions for Labeling the Carbohydrates with the Amine Derivatives by Reductive Amination

作者：Sun Zicai; Wei Zheng; Wei Kemei

来源：Letters in Organic Chemistry, 2009, 6(7): 549-551.

• Amine derivatives
• Reducing carbohydrate
• Reductive amination
• Carbohydrate conjugates
• Reaction mechanism and kinetics
• Reaction conditions

The reaction of the primary amine species with the carbohydrate's reducing end moieties is a kind of special reductive amination reactions which need acid catalysis. The rate equation and selectivity equation of this kind of reactions were given by the kinetic and thermodynamic theories, which can predict the influence of the reaction temperature, pK(a) of used amine and pH on the reaction rate and yield. Based on this theoretical model, researchers can design their route and set the appropriate reaction conditions for immobilization of the carbohydrates or preparation of the carbohydrate conjugates.

• 出版日期2009-10
• 单位福州大学