A peptidic hydrogel that may behave as a %26quot;Trojan Horse%26quot;

作者：Castellucci Nicola; Sartor Giorgio; Calonghi Natalia; Parolin Carola; Falini Giuseppe^*; Tomasini Claudia

来源：Beilstein Journal of Organic Chemistry, 2013, 9: 417-424.

DOI：10.3762/bjoc.9.44

• amino acids
• confocal microscopy
• controlled release
• hydrogel
• low molecular weight hydrogelator

A physical hydrogel prepared with the low-molecular-weight hydrogelator (LMWHG) CH2(C3H6CO-L-Phe-D-Oxd-OH)(2) and water/ethanol mixture was applied as a potential %26quot;Trojan Horse%26quot; carrier into cells. By SEM and XRD analysis we could demonstrate that a fibrous structure is present in the xerogel, making a complex network. The gelator is derived from alpha-amino acids (Thr, Phe) and a fatty acid (azelaic acid) and is biocompatible: it was dosed to IGROV-1 cells, which internalized it, without significantly affecting the cell proliferation. To check the internalization process by confocal microscopy, fluorescent hydrogels were prepared, introducing the fluorescent dansyl moiety into the mixture.

• 出版日期2013-2-22