Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

作者：Tan Hooi Poay^*; Wong Daniel Zin Hua; Ling Sui Kiong; Chuah Cheng Hock; Kadir Habsah Abdul

来源：Fitoterapia, 2012, 83(1): 223-229.

DOI：10.1016/j.fitote.2011.10.019

• Phyllagathis rotundifolia
• Galloylated cyanogenic glucosides
• Hydrolysable tannins
• Neuroprotective
• NG108-15 hybridoma cell line
• H2O2

The galloylated cyanogenic glucosides based on prunasin (1-7), gallotannins (8-14), ellagitannins (15-17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.

• 出版日期2012-1