科研之友
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摘要
A novel and efficient oxidative annulation of 2-aminobenzamides with nitromethane has been developed for the chemoselective synthesis of N-substituted 1,2,3-benzotriazine-4(3H)-ones in moderate to excellent yields under transition metal-free conditions. Two N-N bonds were constructed in one pot via C-N cleavage of nitromethane, which was selectively employed as the nitrogen synthon. The preliminary mechanistic studies revealed that this protocol proceeded under hypoiodite catalysis generated in situ.
