Gold-Catalyzed Intermolecular, anti-Markovnikov Hydroarylation of Methylenecyclopropanes with Indoles

作者:Timmerman Jacob C; Schmitt William W; Widenhoefer Ross A*
来源:Organic Letters, 2016, 18(19): 4966-4969.
DOI:10.1021/acs.orglett.6b02431

摘要

Cationic gold complexes containing an N-hetcrocyclic carbene ligand catalyze the intermolecular anti-Matkovnikov hydroarylation of monosubstituted and cis- and trans-distbstituted methylenecyclopropanes (MCPs) with N-alkyl and 1,2-dialkyl indoles to form the corresponding 3-(cydopropylmethyl)indoles in high regio- and diastereoselectivity and in good to excellent chemical yield.

  • 出版日期2016-10-7