A New Approach to Fluorescence "Turn-On" Sensing of alpha-Amino Acids

作者:Li Zhong'; an; Lou Xiaoding; Li Zhen; Qin Jingui
来源:ACS Applied Materials & Interfaces, 2009, 1(2): 232-234.
DOI:10.1021/am800093d

摘要

For the First time, a conjugated fluorescent polymer was utilized to probe alpha-amino acids, sensitively and selectively, through a new approach. First the strong fluorescence of the prepared polyfluorene (P1) was quenched by trace copper ions, and then the quenched fluorescence was recovered upon the addition of alpha-amino acids, making P1 a new and sensitive biosensor toward alpha-amino acids. The experimental results demonstrated that the alpha-amino acid selective nature of P1 over other analytes was relatively good. Thus, the work reported here might open up a new avenue for developing new biosensors.