Brain blood flow in Andean and Himalayan high-altitude populations: evidence of different traits for the same environmental constraint

作者：Jansen Gerard F A^*; Basnyat Buddha

来源：Journal of Cerebral Blood Flow and Metabolism, 2011, 31(2): 706-714.

DOI：10.1038/jcbfm.2010.150

• adaptation
• Andean
• cerebral blood flow
• high altitude
• Himalayan

Humans have populated the Tibetan plateau much longer than the Andean Altiplano. It is thought that the difference in length of occupation of these altitudes has led to different responses to the stress of hypoxia. As such, Andean populations have higher hematocrit levels than Himalayans. In contrast, Himalayans have increased circulation to certain organ systems to meet tissue oxygen demand. In this study, we hypothesize that cerebral blood flow (CBF) is higher in Himalayans than in Andeans. Using a MEDLINE and EMBASE search, we included 10 studies that investigated CBF in Andeans and Himalayans between 3,658 and 4,330 m altitude. The CBF values were corrected for differences in hematocrit and arterial oxygen saturation. The data of these studies show a mean hematocrit of 50% in Himalayans and 54.1% in Andeans. Arterial oxygen saturation was 86.9% in Andeans and 88.4% in Himalayans. The CBF in Himalayans was slightly elevated compared with sea-level subjects, and was 24% higher compared with Andeans. After correction for hematorit and arterial oxygen saturation, CBF was similar to 20% higher in Himalayans compared with Andeans. Altered brain metabolism in Andeans, and/or increased nitric oxide availability in Himalayans may have a role to explain this difference in brain blood flow. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 706-714; doi:10.1038/jcbfm.2010.150; published online 25 August 2010

• 出版日期2011-2