Affinity chemiresistor sensor for sugars

作者：Tlili Chaker; Badhulika Sushmee; Tran Thien Toan; Lee Ilkeun; Mulchandani Ashok^*

来源：Talanta, 2014, 128: 473-479.

DOI：10.1016/j.talanta.2014.05.055

• Single-walled carbon nanotubes
• Non-enzymatic sensor
• Sugar
• Boronic acid

In this work, a non-enzymatic chemiresistive sugar sensor has been developed by combining a synthetic receptor with aligned single-walled carbon nanotubes (SWNTs) device. Briefly, boronic acid as a multivalent sugar receptor was immobilized on carbon nanotubes through amide bond formation. The interaction between three common sugars (D-glucose, D-fructose and sucrose) and boronic acid modified SWNTs device was studied. The effect of pH on the receptor-ligand binding was examined and highest response was observed at pH 9. The chemiresistive sensor exhibited specific and reproducible detection with sensitivity over the concentration range of 1-20 mM, 1-25 mM, and 1-30 mM for fructose, glucose, and sucrose, respectively. The sensor showed no interference from common electroactive compounds such as citric acid, uric acid, and ascorbic acid. Furthermore, the sensor retained 97.4% of the initial value after five regeneration cycles with an acidic buffer at pH 5, thus ensuring good reusability.

• 出版日期2014-10-1