Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population

作者：Sen Emine; Elgin Kadriye Ufuk; Yuksekkaya Pinar^*; Tirhis Mehmet Hakan; Baran Aksakal Fatma Nur; Teke Mehmet Yasin; Ozturk Faruk

来源：Turkish Journal of Medical Sciences, 2014, 44(4): 687-690.

DOI：10.3906/sag-1303-98

• Corneal biomechanics
• corneal hysteresis
• corneal resistance factor
• intraocular pressure
• ocular response analyzer

Background/aim: To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects.
Materials and methods: There were 404 healthy subjects included prospectively in this study. The subjects were divided into 3 groups (Group 1: 93 subjects aged <18, Group 2: 189 subjects aged between 18 and 59, and Group 3: 122 subjects aged >= 60). Corneal compensated IOP (IOPcc), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer.
Results: When all the study groups were evaluated, a moderately significant negative correlation was found between age and CH and between age and CRF (Spearman's rho = -0.372 and -0.353, respectively; P < 0.0001 for both correlations). There were significant age-related differences among the 3 groups in terms of IOPg, CH, CRF, and central corneal thickness (P = 0.002, P = 0.000, P = 0.000, P = 0.006). There was no confirmation of any difference of IOPcc among the groups (P = 0.427).
Conclusion: The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.

• 出版日期2014