Antitussive arabinogalactan of Andrographis paniculata demonstrates synergistic effect with andrographolide

作者：Nosal'ova Gabriela; Majee Sujay Kumar; Ghosh Kanika; Raja Washim; Chatterjee Udipta Ranjan; Jurecek Ludovit; Ray Bimalendu^*

来源：International Journal of Biological Macromolecules, 2014, 69: 151-157.

DOI：10.1016/j.ijbiomac.2014.05.030

• Andrographis paniculata
• Arabinogalactan
• Andrographolide
• Antitussive activity

Traditional Indian medicines have been used in humans for thousands of years. While the link to a particular indication has been established in man, the active principle of the formulations often remains unknown. In this study, we aim to investigate the structural features and antitussive activity of fractions from Andrographis paniculata leaves. In vivo investigations of water extract (WE), and both ethanolsoluble (WES) and precipitated (WEP) fractions from WE on the citric-acid induced cough efforts and airways smooth muscle reactivity in guinea pigs were performed. Chemical, chromatographic and spectroscopic analysis revealed the existence of a highly branched pectic arabinogalactan (109 kDa) in WEP and andrographolide in WES. WEP showed significant antitussive activity while the potencies of WE and WES are even higher. Neither WE nor WES significantly alter specific airway smooth muscle reactivity. Remarkably, the antitussive activity of arabinogalactan could be increased by synergistic action with andrographolide. Finally, traditional aqueous extraction method provides an arabinogalactan from A. paniculata, which stimulate biological response but without addiction.

• 出版日期2014-8