Nicotabaflavonoidglycoside, the first example of cembranoid and flavonoid heterodimer from Nicotiana tabacum

作者：Yang, Cai-Yan^*; Lin, Yao; Yuan, Hui-Xiong; Yang, Wen-Pei; Wei, Xian; Huang, Zu-Liang

来源：Fitoterapia, 2018, 128: 242-246.

DOI：10.1016/j.fitote.2018.05.028

• Nicotabaflavonoidglycoside
• Cembranoid
• Diterpenoid
• Flavonoid
• Nicotiana tabacum

Nicotabaflavonoidglycoside (1), a novel cembrane-type diterpenoid and flavonoid heterodimer had been isolated from the leaves of Nicotiana tabacum. Its structure was elucidated as (1''S, 6''S) or (1''R, 6''R)-8-[6''-((-)-(1''S, 2''E, 4''Z, 7''E, 11''E)-cembra-2'', 4'', 7'', 11''-tetraenyl)]-rutin by comprehensive analyses of the NMR and HRESIMS spectra. Its absolute configurations of C-1'' and C-6'' were assigned as (1''S, 6''S) by its biogenesis and electronic circular dichroism (ECD). A possible biogenesis involving eliminate reaction of (1S, 2E, 4S, 6R, 7E, 11E)-2, 7, 11-cembratriene-4, 6-diol or its 4R isomer, as well as electrophilic substitution reaction of rutin was postulated.

• 出版日期2018-7
• 单位右江民族医学院