Delayed Nasoseptal Flaps for Endoscopic Skull Base Reconstruction: Proof of Concept and Evaluation of Outcomes

作者：Choby Garret W; Mattos Jose L; Hughes Marion A; Fernandez Miranda Juan C; Gardner Paul A; Snyderman Carl H; Wang Eric W^*

来源：Otolaryngology - Head and Neck Surgery, 2015, 152(2): 255-259.

DOI：10.1177/0194599814561431

• nasoseptal flap
• delayed
• skull base
• CSF leak
• complications
• MRI

Objectives To assess delayed nasoseptal flaps as a viable reconstructive option for sellar defects, evaluate postoperative vascularity of delayed nasoseptal flaps, and compare cerebrospinal fluid leak and surgery-specific complication rates of primary to delayed nasoseptal flaps.
Study Design Case series with chart review.
Setting University of Pittsburgh Medical Center.
Subjects and Methods All patients undergoing transsellar approaches for skull base tumors from 2009 to 2013 were evaluated. In cases where the necessity of a vascularized reconstructive flap was made evident only after tumor resection, the nasoseptal flap was raised after tumor resection and/or cerebrospinal fluid leak development, thus constituting a delayed nasoseptal flap. Outcome measures include postoperative magnetic resonance imaging (MRI) findings, cerebrospinal leak rates, and complication rates.
Results During this timeframe, 437 patients underwent transsellar approaches. Primary nasoseptal flaps were used to reconstruct 179 patients while 32 patients had delayed flaps. All available postoperative MRI scans of delayed nasoseptal flap patients maintained vascularity on examination of T1 postcontrast images. There was no significant difference in cerebrospinal fluid leak rate between primary (3.4%) and delayed flaps (3.1%) (P = .95). There was no significant difference in surgery-specific complication rates between primary flaps (10.6%) and delayed flaps (3.1%; P = .14). Logistic regression analysis demonstrated no significant effect of flap type, age, or sex on cerebrospinal fluid leak rates.
Conclusion Delayed nasoseptal flaps are a viable reconstructive option for sellar skull base defects. They maintain vascularity as evidenced on postoperative MRI and are comparable to primary nasoseptal flaps with regard to cerebrospinal fluid leak rates and complication rates.

• 出版日期2015-2