Novel Findings of Anti-cancer Property of Propofol

作者：Wang, Jiaqiang; Cheng, Chien-shan; Lu, Yan; Ding, Xiaowei; Zhu, Minmin; Miao, Changhong^*; Chen, Jiawei^*

来源：Anti-Cancer Agents in Medicinal Chemistry, 2018, 18(2): 156-165.

DOI：10.2174/1871520617666170912120327

• Propofol
• anesthetic
• general anesthesia
• neoplasms
• anti-cancer
• malignance-modulating

Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. @@@ Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. @@@ Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.

• 出版日期2018
• 单位复旦大学