Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

作者：Kim Kyungim; Oh Keun Sang; Park Dal Yong; Lee Jae Young; Lee Beom Suk; Kim In San; Kim Kwangmeyung; Kwon Ick Chan; Kim SangYoon; Yuk Soon Hong^*

来源：Journal of Controlled Release, 2016, 228: 141-149.

DOI：10.1016/j.jconrel.2016.03.009

• Combination therapy
• Radiotherapy
• Core/shell nanoparticles
• Gold nanoparticles
• Doxorubicin

A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

• 出版日期2016-4-28