Aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings: fabrication and application in biosensing

作者：Hsiao Vincent K S; Waldeisen John R; Zheng Yuebing; Lloyd Pamela F; Bunning Timothy J; Huang Tony Jun^*

来源：Journal of Materials Chemistry, 2007, 17(46): 4896-4901.

DOI：10.1039/b711200a

We have fabricated aminopropyltriethoxysilane (APTES)-functionalized nanoporous polymeric gratings by combining holographic interference patterning and APTES-functionalization of the pre-polymer syrup. The APTES facilitates the immobilization of biomolecules onto the polymeric grating surfaces. The successful detection of multiple biomolecules (biotin, steptavidin, biotinylated anti-rabbit IgG, and rabbit-IgG) indicates that the functionalized nanoporous polymeric gratings can act as biosensing platforms which are label-free, inexpensive, and applicable as high-throughput assays.

• 出版日期2007