A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to gamma-amino and gamma-carbamato-alpha,beta-enoates

作者：Rastogi Shiva K; Kornienko Alexander^*

来源：Tetrahedron: Asymmetry , 2006, 17(22): 3170-3178.

DOI：10.1016/j.tetasy.2006.11.029

Various substituted arylcuprates undergo stereocontrolled additions to L-serine-derived gamma-amino- and gamma-carbamato-alpha,beta-enoates with high syn-selectivities. The stereochemical outcome of these reactions is fully consistent with the reductive elimination-based model proposed previously. This method is well suited for the preparation of a broad range of biologically active amaryllidaceae constituents and their aromatic analogues.

• 出版日期2006-11-27