Desmopressin-induced Posterior Reversible Encephalopathy Syndrome

作者：Wei Ruili; Jin Lu; Huang Jianhe; Luo Benyan^*

来源：Internal Medicine, 2012, 51(21): 3081-3084.

DOI：10.2169/internalmedicine.51.8245

• posterior reversible encephalopathy syndrome
• desmopressin
• hyponatremia
• vasogenic edema
• hypertension
• magnetic resonance imaging

We herein report the case of a patient who presented with an acute decrease of visual acuity, hypertension, focal seizures and transient mental dysfunction while undergoing desmopressin treatment. Neuroimaging revealed bilateral occipital-parietal lesions that presented with vasogenic edema. After controlling the hypertension and discontinuing the desmopressin treatment, the patient's condition improved. A follow-up imaging examination performed six months later showed complete resolution of the lesions. It is important to recognize posterior reversible encephalopathy syndrome (PRES) as a rare and serious complication of desmopressin administration. Both the blood pressure and water electrolyte balance should be carefully monitored in patients receiving desmopressin therapy.

• 出版日期2012
• 单位温州医科大学; 浙江大学