Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates

作者：Higgins Paul G^*; Stubbings Will; Wisplinghoff Hilmar; Seifert Harald

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(4): 1613-1615.

DOI：10.1128/AAC.01637-09

This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH, and that of ciprofloxacin against Acinetobacter baumannii under standard conditions (pH 7.2) and at a pH of 5.8. Overall, finafloxacin demonstrated superior activity to ciprofloxacin under acidic conditions. Furthermore, finafloxacin showed comparable activity to ciprofloxacin at pH 7.2. Hence, finafloxacin could be a promising new antimicrobial agent for the treatment of A. baumannii infections at acidic body compartments.

• 出版日期2010-4
• 单位河北医科大学