LONG-TERM IMMUNOGENICITY OF TWO PEDIATRIC DOSES OF COMBINED HEPATITIS A AND B OR MONOVALENT HEPATITIS B VACCINE IN 8 TO 10-YEAR-OLD CHILDREN AND THE EFFECT OF A CHALLENGE DOSE GIVEN SEVEN YEARS LATER

作者：Gilca Vladimir^*; Dionne Marc; Boulianne Nicole; Murphy Donald; De Serres Gaston

来源：Pediatric Infectious Disease Journal, 2009, 28(10): 916-918.

DOI：10.1097/INF.0b013e3181a3ad28

• hepatitis A and B
• vaccination
• 2 doses
• long term
• booster

A total of 465 children aged 8 to 10 years were vaccinated with 2 doses of Recombivax-HB 2.5 mu g (RB) or Twinrix-Junior 10 ug/360 EL.U (TX), according to a 0 and 6 months schedule. Seven years postsecond dose, a challenge dose of vaccine was given. All vaccinees in the TX and 98% in the RB group showed an anamnestic response. Vaccination at the age of 8 to 10 years with two-pediatric doses of TX or RB given with a 6 months interval induces a long-lasting immunity in most vaccinees.

• 出版日期2009-10