Embelin inhibits abdominal aortic aneurysm through decreasing IL-6-induced STAT3 and NF-kappa B inactivation

作者：Liu, Qiang; Wang, Qingshan^*; Li, Haibin

来源：Molecular Medicine Reports, 2018, 18(2): 2365-2372.

DOI：10.3892/mmr.2018.9221

• embelin
• abdominal aortic aneurysm
• interleukin-6
• signal transducer and activator of transcription 3
• nuclear factor-kappa B

The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA). AAA model mice were induced by chronic infusion of 1,000 ng/kg/min Angiotensin II. AAA model mice were treated with 25, 50 or 100 mg/kg embelin for 28 days. Embelin inhibited tumor necrosis factor-, interleukin (IL)-1, IL-6, IL-18 and malondialdehyde (MDA) level activities, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase level activities and inhibited MDA level activities in AAA mice Embelin suppressed the secretion of matrix metalloproteinase-9 protein expression, monocyte chemoattractant protein-2 activity and epithelial neutrophil-activating peptide expression levels in AAA mice. Embelin suppressed phosphorylated-signal transducer and activator of transcription (STAT) 3, phosphorylated-p38 mitogen-activated protein kinase and nuclear factor (NF)-B protein expression in AAA mice. These findings indicate that embelin inhibits AAA through decreasing IL-6-induced STAT3, and NF-B inactivation.

• 出版日期2018-8
• 单位黑龙江省医院