The genetic susceptibility to IgA nephropathy: A novel functional candidate gene for incomplete O-glycosylation of IgA1

作者：Narita I^*; Kaneko Y; Kondo D; Goto S; Sakatsume M; Gejyo F

来源：Kidney International, 2007, 71(5): 379-381.

DOI：10.1038/sj.ki.5002139

Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.

• 出版日期2007-3