An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

作者：Ali F R; Barton A; Smith R L I; Bowes J; Flynn E; Mangino M; Bataille V; Foerster J P; Worthington J; Griffiths C E M; Warren R B^*

来源：British Journal of Dermatology, 2013, 168(4): 864-866.

DOI：10.1111/bjd.12106

Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. %26lt;br%26gt;Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. %26lt;br%26gt;Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U. K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. %26lt;br%26gt;Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. %26lt;br%26gt;Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

• 出版日期2013-4