An efficient solvent-tuning approach for the rapid synthesis of thiazolidinone derivatives and the selective synthesis of 2-amino-4H-1,3-thiazin-4-one and dimethyl 3,3 %26apos;-thiodiacrylates

作者：Choudhary Garima; Peddinti Rama Krishna^*

来源：Tetrahedron Letters, 2014, 55(41): 5597-5600.

DOI：10.1016/j.tetlet.2014.08.032

• Catalyst-free
• Solvent tuning
• Ethyl lactate
• Thiazolidinone
• 1,3-Thiazinone

Green synthetic approach has been developed for the rapid generation of thiazolidinone derivatives as crystallized products under catalyst-free conditions in water by polarity adjustment with ethyl lactate as a co-solvent in excellent yields. Additionally, interesting findings on the synthesis of 2-amino-4H-1,3-thiazin-4-one and dimethyl 3,3%26apos;-thiodiacrylates have been reported.

• 出版日期2014-10-8