Novel self-assembly-induced 3D plotting for macro/nano-porous collagen scaffolds comprised of nanofibrous collagen filaments

作者：Shin Kwan Ha; Kim Jong Woo; Koh Young Hag^*; Kim Hyoun Ee

来源：Materials Letters, 2015, 143: 265-268.

DOI：10.1016/j.matlet.2014.12.119

• Biomaterials
• Biomimetic
• Microstructure
• Porous materials
• Polymers

This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/ nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (similar to 451 x 305 mu m in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of similar to 353 kPa and compressive strength of similar to 31 kPa at a porosity of similar to 95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.

• 出版日期2015-3-15