New prognostic model for extranodal natural killer/T cell lymphoma, nasal type

作者：Cai, Qingqing^*; Luo, Xiaolin; Zhang, Guanrong; Huang, Huiqiang; Huang, Hui; Lin, Tongyu; Jiang, Wenqi; Xia, Zhongjun; Young, Ken H.

来源：Annals of Hematology, 2014, 93(9): 1541-1549.

DOI：10.1007/s00277-014-2089-x

• Extranodal natural killer/Tcell lymphoma
• Prognostic model
• Total protein
• Fasting blood glucose
• Korean Prognostic Index

Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) < 60 g/L, fasting blood glucose (FBG) > 100 mg/dL, and Korean Prognostic Index (KPI) score a parts per thousand yen2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p < 0.001). Our new prognostic model had a better prognostic value than did the KPI model alone (p < 0.001). Our proposed prognostic model for ENKTL, including the newly identified prognostic indicators, TP and FBG, demonstrated a balanced distribution of patients into different risk groups with better prognostic discrimination compared with the KPI model alone.

• 出版日期2014-9
• 单位广东省人民医院; 中山大学