Application of beta-Hydroxysulfoximines in catalytic asymmetric phenyl transfer reactions for the synthesis of diarylmethanols

作者：Sedelmeier Joerg; Bolm Carsten^*

来源：Journal of Organic Chemistry, 2007, 72(23): 8859-8862.

DOI：10.1021/jo7016718

[GRAPHICS]
Enantiomerically enriched diarylmethanols have been prepared by catalyzed asymmetric phenyl transfer reactions onto aromatic aldehydes with use of readily available beta-hydroxysulfoximines as catalysts. As the aryl source, combinations of diethylzinc with either diphenylzinc or triphenylborane have been applied affording aryl phenylmethanols with up to 93% ee in good yields. Various functionalized aldehydes and heterocyclic substrates are tolerated, yielding synthetically relevant products.

• 出版日期2007-11-9