Assessment of Chimpanzee Adenovirus Serotype 63 Neutralizing Antibodies Prior to Evaluation of a Candidate Malaria Vaccine Regimen Based on Viral Vectors

作者：Nebie Issa^*; Edwards Nick J; Tiono Alfred B; Ewer Katie J; Sanou Guillaume S; Soulama Issiaka; Sanon Souleymane; Diarra Amidou; Yaro Jean Baptiste; Kangoye David; Imoukhuede Egeruan B; Hill Adrian V S; Sirima Sodiomon B

来源：Clinical and Vaccine Immunology, 2014, 21(6): 901-903.

DOI：10.1128/CVI.00723-13

Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected to assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low neutralizing antibody titers reported in both adults and children (median titers, 139.1 and 35.0, respectively) are encouraging for the potential use of ChAd63 as a malarial vaccine vector.

• 出版日期2014-6