Development of a quality evaluation system for Panax quinquefolium. L based on HPLC chromatographic fingerprinting of seven major ginsenosides

作者：Chen Junhui; Xie Mingyong^*; Fu Zhihong; Lee Frank Sen Chun; Wang Xiaoru

来源：Microchemical Journal, 2007, 85(2): 201-208.

DOI：10.1016/j.microc.2006.05.007

• high-performance liquid chromatography
• Panax quinquefolium. L
• ginsenoside
• quality evaluation system
• hierarchical clustering analysis

A HPLC fingerprinting method based on the distribution and contents of seven major ginsenosides has been developed for the quality evaluation of Panax quinquefolium. L roots cultivated in China, Singapore and Canada. The method is ideally suited for the fingerprinting of P. quinquefolium. L samples or its derived products for sample authentication or quality control, e.g. pharmaceutical stability studies. Different extraction methods have been evaluated and a protocol established to maximize the gensinosides yields in routine operations. Hierarchical clustering analysis of the fingerprints demonstrates that the distribution and contents of ginsenosides in P quinquefolium. L root vary depending on geographic location; and the quality of Jilin-cultivated P quinquefolium. L roots is similar in composition to Canada-cultivated ones, which are generally considered among the best quality in P quinquefolium. L.

• 出版日期2007-4
• 单位中国海洋大学; 国家海洋局第一海洋研究所; 南昌大学