Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function

作者：Golan Ron; Scovell Jason M; Ramasamy Ranjith^*

来源：Aging Male, 2015, 18(3): 201-204.

DOI：10.3109/13685538.2015.1052392

• Aging
• testosterone
• hypogonadism
• late-onset hypogonadism

Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

• 出版日期2015-7-3