Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes

作者：de Tassigny Alexandra d'Anglemont; Assaly Rana; Schaller Sophie; Pruss Rebecca M; Berdeaux Alain; Morin Didier^*

来源：Mitochondrion, 2013, 13(6): 688-697.

DOI：10.1016/j.mito2013.10.001

• Cardiomyocytes
• Doxorubicin
• Mitochondria
• Permeability transition pore
• ROS
• TSPO ligands

Contractile dysfunction and subsequent development of cardiomyopathies are well known limiting factors in the treatment of cancer with doxorubicin and have been linked to mitochondrial dysfunction. Here, using adult isolated paced cardiomyocytes, we have demonstrated that ligands of translocator protein (TSPO) 4'-chlorodiazepam and TRO40303 prevented the doxorubicin-induced alterations in contractility and improved cardiomyocyte viability. This cardioprotective effect was closely associated with both a potent reduction in reactive oxygen species production and inhibition of mitochondrial permeability transition pore opening. Thus, preventive admini

• 出版日期2013-11