Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin

作者：Kosheleva N V^*; Chernyak E I; Polienko Yu F; Morozov S V; Grigor'ev I A

来源：Chemistry of Natural Compounds, 2014, 50(2): 261-265.

DOI：10.1007/s10600-014-0927-7

• dihydroquercetin
• nitroxyl radicals
• spin-labeled compounds
• Mannich reaction

Mono-substituted spin-labeled compounds were synthesized from Mannich reactions of dihydroquercetin with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl. According to preliminary data, the compounds possessed antioxidant activity and selective cytotoxicity against various tumor cells and were promising for biomedical tests including magnetic resonance tomography.

• 出版日期2014-5