Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage

作者：Chen, Xian; Yin, Biao; Lian, Ruo-Chun; Zhang, Tao; Zhang, Hong-Zhan; Diao, Liang-Hui; Li, Yu-Ye; Huang, Chun-Yu; Liang, De-Sheng^*; Zeng, Yong^*

来源：American Journal of Reproductive Immunology, 2016, 76(6): 432-438.

DOI：10.1111/aji.12585

• 1
• 25-dihydroxyvitamin D
• NK cytotoxicity
• peripheral blood lymphocyte
• recurrent miscarriage
• Th1 cytokines

ProblemWe aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM). @@@ Method of studyThe effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM. @@@ ResultsThe percentage of CD19(+) B cells and NK cytotoxicity at an effector-to-target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (VDI) than in the vitamin D normal group (VDN) (P<.05 each). The proportion of TNF--expressing Th cells was significantly higher in the vitamin D deficiency group (VDD) than in VDN (P<.05). However, there were no significant differences between VDI and VDD. This dysregulation was significantly reduced with 1,25(OH)(2)D supplementation. @@@ ConclusionThe data suggest that the abnormalities of cellular immune response were observed in RM patients with a low vitamin D level, which could be regulated to some extent with 1,25(OH)(2)D supplementation.

• 出版日期2016-12
• 单位中南大学