Mechanical properties of double-stranded DNA biofilm with Gaussian distribution

作者：Tang, Heng-Song; Meng, Wei-Lie; Zhang, Neng-Hui^*

来源：Acta Mechanica Sinica, 2014, 30(1): 15-19.

DOI：10.1007/s10409-014-0023-z

• Double-stranded DNA
• Biofilm
• Elastic modulus
• Cylinder model
• Gaussian distribution

In microcantilever-based label-free biodetection technologies, deflection changes induced by adsorptions of double-stranded DNA (dsDNA) molecules on Au-layer surface are greatly affected by the mechanical, thermal and electrical properties of DNA biofilm. In this paper, the elastic properties of dsDNA biofilm are studied. First, the Parsegian's empirical potential based on a mesoscopic liquid crystal theory is employed to describe the interaction energy among coarse-grained DNA cylinders. Then, considering a Gaussian distribution of DNA interaxial distance, the thought experiment method is used to derive an analytical expression for Young's modulus of DNA biofilm with a stochastic packing pattern for the first time. Results show that Young's modulus of DNA biofilm is on the order of 10MPa. These findings could provide a simple and effective method to evaluate the mechanical properties of soft biofilm on substrate.

• 出版日期2014-2
• 单位上海大学