Cooperative Catalysis Approach to Intramolecular Hydroacylation

作者:Beletskiy Evgeny V; Sudheer Ch; Douglas Christopher J*
来源:Journal of Organic Chemistry, 2012, 77(14): 5884-5893.
DOI:10.1021/jo300779q

摘要

Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.

  • 出版日期2012-7-20