Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure

作者：Saillenfait Anne Marie^*; Sabate Jean Philippe; Robert Alain; Cossec Benoit; Roudot Alain Claude; Denis Flavien; Burgart Manuella

来源：Reproductive Toxicology, 2013, 42: 192-202.

DOI：10.1016/j.reprotox.2013.09.004

• Developmental toxicity
• Rat
• Diisooctyl phthalate
• Phthalic acid esters
• Embryotoxicity
• Male reproductive system
• Antiandrogen
• In utero exposure

In a first study, rats were given diisooctyl phthalate (DIOP, CAS 27554-26-3) at 0, 0.1, 0.5, and 1 g/kg/day, by gavage, on gestation days 6-20 (GD). There was a significant increase in resorptions at 1 g/kg/day and a reduction in fetal weights at 0.5 and 1 g/kg/day. Malpositioned testes were observed in fetuses at 1 g/kg/day, and supernumerary lumbar ribs and ossification delay at 0.5 and 1 g/kg/day. In a follow-up study, DIOP administered on GD 12-19 reduced fetal testicular testosterone at 0.1 g/kg/day and above. Finally, postnatal reproductive assessment was conducted in adult male offspring prenatally exposed to DIOP on GD 12-21. Abnormalities of reproductive system (e.g. hypospadias, non scrotal testes, and hypospermatogenesis) were observed in a few adult males at 0.5 g/kg/day, and with a high incidence at 1 g/kg/day. Thus, DIOP displayed an antiandrogenic activity and disrupted the male reproductive development.

• 出版日期2013-12