Adoptive T Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cytomegalovirus Disease in a Renal Transplant Recipient

作者：Macesic N; Langsford D; Nicholls K; Hughes P; Gottlieb D J; Clancy L; Blyth E; Micklethwaite K; Withers B; Majumdar S; Fleming S; Sasadeusz J^*

来源：American Journal of Transplantation, 2015, 15(3): 827-832.

DOI：10.1111/ajt.13023

Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.
Adoptive T cell immunotherapy using cytomegalovirus-specific T cells from a donor bank is used as salvage therapy in a case of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.

• 出版日期2015-3