The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine

作者：Matsui Hirofumi^*; Shimokawa Osamu; Kaneko Tsuyoshi; Nagano Yumiko; Rai Kanho; Hyodo Lchinosuke

来源：Journal of Clinical Biochemistry and Nutrition, 2011, 48(2): 107-111.

DOI：10.3164/jcbn.10-79

• Non-steroidal anti-inflammatory drugs
• gastrointestinal mucosal injury
• mitochondria
• lipid peroxidation
• reactive oxygen species

Non-steroidal anti-inflammatory drugs are the most commonly prescribed drugs for arthritis, inflammation, and cardiovascular protection. However, they cause gastrointestinal complications. The pathophysiology of these complications has mostly been ascribed to non-steroidal anti-inflammatory drugs' action on the cyclooxygenase inhibition and the subsequent prostaglandin deficiency. However, recent clinical demonstrated the prevalence of non-steroidal anti-inflammatory drugs-induced small intestinal mucosal injury is more often than previously expected. In this review, we discuss the defense mechanisms of stomach, and the pathophysiology of non-steroidal anti-inflammatory drugs-induced injury of stomach and small intestine, especially focused on nonsteroidal anti-inflammatory drugs' action on mitochondria.

• 出版日期2011-3-2