科研之友
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摘要
Introduction: Drug induced gingival hyperplasia is the overgrowth of gingival ephitelium and submucosa which may cause bleeding and loss of teeth. Certain anticonvulsing, immunosuppressive and antihypertensive drugs are the underlying cause in most cases. Among them, cases due to amlodipine are very rare. Here we discuss the topic along with a case of gingival overgrowth induced by amlodipine.
Case presentation: A sixty-three-year-old male presented with gingival overgrowth and hemorrhage. He was on warfarin and amlodipin because of prosthetic aortic valve and primary hypertension. He had gingival hyperplasia increasingly growing in the last couple of months. His antihypertensive regimen was readjusted with cessation of amlodipine.
Discussion: The pathogenesis of drug induced gingival hyperplasia is not totally understood yet, it is obviously related to gingival infalmmation. Treatment strategy is cessation of the inducing agent, providing oral hygiene and gingivectomy if necessary. Concomitant use of warfarin in our patient was another contributing factor for his tendency to gingival hemorrhage. Replacing amlodipine with different antihypertensives and appropriate dental care ensured the recovery of gingival lesions in the follow up period. The patient continued warfarin treatment without hemorrhagic complications.
Conclusion: Calcium channel blockers (CCB) are antihypertensives that we commonly prescribe. We may be able to avoid serious complications if we bear in mind that these drugs may cause gingival overgrowth especially when dental care is poor.
- 出版日期2016
