Amyotrophic lateral sclerosis Prospective study on respiratory parameters

作者：Meira Almeida Sara Regina; Silva Luciano Bruno C; Guerreiro Carlos Alberto M; Nucci Anamarli^*

来源：Arquivos de Neuro-Psiquiatria, 2010, 68(2): 258-262.

DOI：10.1590/S0004-282X2010000200020

• amyotrophic lateral sclerosis
• maximum inspiratory pressure
• maximum expiratory pressure
• body mass index

Objective: To verify how efficient respiratory parameters are in the follow-up of subjects with amyotrophic lateral sclerosis (ALS) and to observe possible correlations between respiratory and nutritional functions. Method: Sixteen patients with probable or defined ALS were selected and evaluated over eight months using the following respiratory parameters: spirometry, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), arterial gasometry and pulse oximetry; and nutritional parameters such as body mass index (BMI) and percentage weight loss. Results: P(a)CO(2) was a significant parameter to follow up disease evolution (p=0.051). There was significant correlation between MIP and MEP (r: 0.83); BMI and MIP (r: 0.70); BMI and MEP (r: 0.72); pulse oximetry and forced vital capacity (r: 0.57). Conclusion: P(a)CO(2) was shown to be an efficient and significant parameter in the measurement of respiratory impairment; the correlations among MIP, MEP and BMI indicated that these are significant parameters for periodic clinical evaluation.

• 出版日期2010-4