A versatile method for the synthesis of heterocyclic ring-fused 1,2-oxazinones from the NHC-catalyzed reactions of 2-aroylvinylarylaldehydes with nitrosoarenes

作者：Qu, Jing; Cheng, Ying^*

来源：Tetrahedron, 2013, 69(2): 888-894.

DOI：10.1016/j.tet.2012.10.089

• N-Heterocyclic carbene-catalysis
• 2-Aroylvinylarylaldehyde
• Furo[3,4-d][1,2]oxazin-4-one
• Thieno[3,4-d][1,2]oxazin-4-one
• Pyrido[3,2-d][1,2]oxazin-5-one

The NHC-catalyzed reactions of nitrosoarenes with 4-(2-aroylvinyl)furan-3-carbaldehydes, 4-(2-aroylvinyl) thiophene-3-carbaldehydes or 2-(2-aroylvinyl)nicotinaldehydes were studied, which produced novel furo[3,4-d][1,2]oxazin-4-ones, thieno[3,4-d][1,2]oxazin-4-ones or pyrido[3,2-d][1,2]oxazin-5-ones, respectively. This work developed a versatile method for the construction of different types of heterocyclic ring-fused 1,2-oxazinones that are not easy accessible by other methods.

• 出版日期2013-1-14
• 单位北京师范大学