A structural biology perspective on bioactive small molecules and their plant targets

作者：Kumari Selva; van der Hoorn Renier A L^*

来源：Current Opinion in Plant Biology, 2011, 14(5): 480-488.

DOI：10.1016/j.pbi.2011.06.003

Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.

• 出版日期2011-10