Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice

作者：Wang, Jinhui; Hu, Shiwei^*; Jiang, Wei; Song, Wendong; Cai, Lu; Wang, Jingfeng

来源：International Immunopharmacology, 2016, 31: 15-23.

DOI：10.1016/j.intimp.2015.12.009

• Fucoidan
• Sea cucumber
• Inflammatory response
• Insulin resistance

Nutrition excess-induced inflammation positively contributed to insulin resistance. Fucoidan from sea cucumber can increase glucose translocation in skeletal muscle. However, its effects on inflammation-associated insulin resistance are not understood. We investigated fucoidan from Isostichopus badionotus (Ib-FUC)-alleviated inflammatory response and signaling as well as -improved insulin resistance in the liver of obesity mice. The results showed that Ib-FUC reduced body weight and glucose levels, increased insulin sensitivity, and inhibited serum lipid concentrations. Meanwhile, Hepatic glycogen synthesis was promoted by Ib-FUC via activation of the PI3K/PKB/GSK-3 beta signaling and regulation of glucose metabolism-related enzymatic activities. Ib-FUC regulated serum inflammatory cytokines and their mRNA expression in the liver. Ib-FUC-induced inactivation of the JNK and IKK beta/NF kappa beta pathways was involved in the activation of insulin signal cascade and inflammatory factor production. These findings suggested that Ib-FUC supplementary-induced alleviation of inflammatory response could be a mechanism responsible for its beneficial effects against hepatic insulin resistance.

• 出版日期2016-2
• 单位中国海洋大学; 浙江海洋大学