A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): Identification, synthesis and antinociceptive activity

作者:Radulovic Niko*; Dordevic Nevenka; Denic Marija; Gomes Pinheiro Mariana Martins; Fernandes Patricia Dias; Boylan Fabio
来源:Food and Chemical Toxicology, 2012, 50(2): 274-279.
DOI:10.1016/j.fct.2011.10.060

摘要

2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin%26apos;s strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20 mg/kg). It was found to be lethal in doses higher than 20 mg/kg.

  • 出版日期2012-2