Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles

作者：Han Xiao; Luo Jie; Liu Chen; Lu Yixin^*

来源：Chemical Communications, 2009, (15): 2044-2046.

DOI：10.1039/b823184b

Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thiourea catalysts generated the desired Michael products containing vicinal fluorinated quaternary and tertiary chiral centers with exceptional enantioselectivity.

• 出版日期2009